Hormonal contraceptive use related to breast cancer among women in Indonesia: a nationwide study

Solikhah Solikhah, Monthida Sangruangake, Ratu Matahari, Wulan Rahmadhani, Rochana Ruliyandari


Breast cancer is a non-contagious disease and remains a global problem, including Indonesia. However, research findings in regard to the influence of hormonal contraceptive use on carcinogenesis in breast cancer have not been conclusive. Therefore, this study aimed to investigate whether there was any association between hormonal contraception use and breast cancer among women in Indonesia.  We assessed 3,517 participants aged above 30 years, who had participated in a population-based, cross-sectional study conducted through the Indonesian Family Life Survey wave five during 2014-2015. A logistic regression model was performed to analyse data with a 95% confidence interval and p <0.05 significance. As many as 3,228 respondents (91.78%) were selected out of a total of 3,517 women using hormonal contraceptive. The majority of them were aged between 30-39 at the commencement of this study. The precentage of breast cancer cases in this study was 0.34%, with a total of 1,574 respondents (44.75%) having used hormonal contraceptive for more than five years. After controlling for confounders, the hormonal contraceptive use had significantly lower to have breast cancer incidence (ORadj=0.10; 95% CI=0.03-0.40; p<0.05) compared to women using non-hormonal contraceptive, while the long-term hormonal contraception use (more than five years) did not affect breast cancer incidence. Hormonal contraceptive use was associated with breast cancer; however, the evidence from our findings indicated that the magnitude of the risk was small.  Understandably, long-term hormonal contraceptive had no significant effect on causing breast cancer. This study indicates that hormonal contraceptive use could signify a vital induction window for breast cancer and increasing knowledge when selecting the right contraceptives for use.

DOI: http://doi.org/10.11591/ijphs.v11i3.21560


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International Journal of Public Health Science (IJPHS)
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