Rapid Antibody Test Sensitivity and Spesitivity as COVID 19 Screening Methode in Sleman Regency

Atikah Nurhesti, Solikhah Solikhah, Siti Nur Djannah

Abstract


Coronavirus Disease (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Antibody rapid test is one of the COVID-19 screening tests that can be used in the community. Therefore, the purpose of this study was to assess the sensitivity and specificity, also positive predictive value (PPV) and negative predictive value (NPV) of the rapid antibody rest as a method of screening for COVID 19 in Sleman Regency.  In total, 118 respondents were enrolled in this study; 76 respondents were reactively detected by using a rapid antibody test. The sensitivity value was 97.33%, and the specificity value was 93.02%, while the positive predictive value (NPP) was 96.05%, and the negative predictive value (NPN) was 95.24%. These results meet the minimum recommendations for the screening method.

Keywords:

COVID-19, Antibody Rapid Test, Sensitivity, Specificity, Screening


References


Tian S, Hu N, Lou J, et al. Characteristics of COVID-19 infection in Beijing. J Infect. 2020;80(4):401-406. doi:10.1016/j.jinf.2020.02.018

Gugus Penanganan COVID-19. Peta Sebaran. Peta Sebaran. 2020:diakses 13 Agustus 2020.

Dinas Kesehatan Kabupaten Sleman. Dashboard Informasi COVID-19 Kabupaten Sleman. 2020:diakses pada 13 Agustus 2020.

Kopel J, Goyal H, Perisetti A. Antibody Tests for Auto Antibody. Baylor Univ Med Cent Proc. 2020;34(1):63-72. http://www.healthcommunities.com/blood-tests/antibody-test-autoimmune-disorders.shtml.

Li Z, Yi Y, Luo X, et al. Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis. J Med Virol. 2020;92(9):1518-1524. doi:10.1002/jmv.25727

Mandavilli A. Coronavirus Antibody Tests: Can You Trust the Results? The New York Times. https://www.nytimes.com/2020/04/24/health/coronavirus-antibody-tests.html. Published 2020.

Castro R, Luz PM, Wakimoto MD, Veloso VG, Grinsztejn B, Perazzo H. COVID-19: A Meta-Analysis of Diagnostic Test Accuracy of Commercial Assays Registered in Brazil. Brazilian J Infect Dis. 2020;24(2):180-187. doi:10.1016/j.bjid.2020.04.003

Bundschuh C, Egger M, Wiesinger K, Al E. Evaluation of the EDI enzyme linked immunosorbent assays for the detection of SARS-CoV-2 IgM and IgG antibodies in human plasma. Clin Chim Acta. 2020;509:18-21. doi:10.1016/j.cca.2020.05.049

Nicol T, Lefeuvre C, Serri O, Al E. Assesment of SARS-CoV-2 serological test for the diagnosis of COVID-19 through the evaluation of three immunoassays : two automated immunoassays (Euroimmun and Abbott) and one rapid lateral flow immunoassays (NG Biotech). J Clin Virol. 2020;129(104511). doi:10.1016/j.jcv.2020.104511

Haselmann V, Kittel M, Gerhards C, Al E. Comparison of test performance of commercial anti-SARS-CoV-2 immunoassays in serum and plasma samples. Clin Chim Acta. 2020;510:73-78. doi:10.1016/j.cca.2020.07.007

Jaaskelainen A, Kuivanen S, Kekalainen E, Al E. Performance of six SARS-CoV-2 immunoassays in comparison with microneutralisation. J Clin Virol. 2020;129(104512). doi:10.1016/j.jcv.2020.104512

Montesinos I, Gruson D, Kabamba B, Al E. Evaluation of two automated and three rapid lateral flow immunoassays for detection of anti-SARS-CoV-2 antibodies. J Clin Virol. 2020;128(104413). doi:10.1016/j.jcv.2020.104413

Serrano M, Rodriguez D, Palop N, Al E. Comparasion of comercial lateral flow immunoassays and ELISA for SARS-CoV-2 antibody detection. J Clin Virol. 2020;129(104529). doi:10.1016/j.jcv.2020.104529

Shen B, Zheng Y, Zhang X, Al E. Clinical evaluationof a rapid coloidal gold immunochromatography assay for SARS-CoV-2 IgM/IgG. Am J Transl Res. 2020;12(4):1348-1354.

Centers for Disease Control and Prevention. Interim Guidelines for COVID-19 Antibody Testing in Clinical and Public Health Settings. Atlanta; 2020.

Europian Commission. Guidelines on COVID-19 in Vitro Diagnostic Test and Their Performance.; 2020.

Rachman BE, Rusli M, Miftahussurur M. The hidden vulnerability of COVID-19 observed from asymptomatic cases in Indonesia. Syst Rev Pharm. 2020;11(2):703-713. doi:10.31838/srp.2020.2.103

Hoffman T, Nissen K, Krambrich J, et al. Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2. Infect Ecol Epidemiol. 2020;10(1). doi:10.1080/20008686.2020.1754538

Bisoffi Z, Elena P, Deiana M, et al. Sensitivity, Specificity and Predictive Values of Molecular and Serological Tests for COVID-19.; 2020.

Beeching NJ, Fletcher TE. Covid-19 : testing times. BMJ. 2020;396(1403).

Reitsma JB, Glas AS, Rutjes AWS, Scholten RJPM, Bossuyt, P. M Zwinderman AH. Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews. Journal of Clinical Epidemiology. J Clin Epidemiol. 2005;58(10):982-990. doi:doi.org/10.1016/j.jclinepi.2005.02.022

Owusu-Ansah E de-GJ, Sampson A, Samuel AK, Robert A. Sensitivity and Specificity Analysis Relation to Statistical Hypothesis Testing and Its Errors: Application to Cryptosporidium Detection Techniques. Open J Appl Sci. 2016;06(04):209-216. doi:10.4236/ojapps.2016.64022

Ye F, Xu S, Rong Z, Xu R, Liu X, Deng P. Delivery of infection from asymptomatic carriers of COVID-19 in a familial cluster. Int J Infect Dis. 2020;(January). doi:https://doi.org/10.1016/j.ijid.2020.03.042

Meng X, Deng Y, Dai Z, Meng Z. COVID-19 and anosmia: A review based on up-to-date knowledge. WwwElsevierCom/Locate/Amjoto. 2020;(January):1-6. doi:https://doi.org/10.1016/j.amjoto.2020.102581

Susilo A, Rumende CM, Pitoyo CW, et al. Coronavirus Disease 2019: Tinjauan Literatur Terkini. J Penyakit Dalam Indones. 2020;7(1):45. doi:10.7454/jpdi.v7i1.415

Xie J, Ding C, Li J, et al. Characteristics of Patients with Coronavirus Disease (COVID-19) Confirmed using an IgM-IgG Antibody Test. J Med Virol. 2020;(April):1-7. doi:10.1002/jmv.25930

Akobeng AK. Understanding diagnostic tests 1: Sensitivity, specificity and predictive values. Acta Paediatr Int J Paediatr. 2007;96(3):338-341. doi:10.1111/j.1651-2227.2006.00180.x

Li H, Liu Z, He Y, et al. A new and rapid approach for detecting COVID‐19 based on S1 protein fragments. Clin Transl Med. 2020;10(2):6-11. doi:10.1002/ctm2.90

Cassaniti I, F N, F G, Al E. Performance of VivaDiag COVID-19 IgM/IgG Rapid Test is inadequate for diagnosis of COVID-19 in acute patients referring to emergency room department. J Med Virol. 2020;10. doi:10.1002/jmv.25800

WHO. Advice on the Use of Point-of-Care Immunodiagnostic Tests for COVID-19 Rapid Diagnostic Tests Based on Antigen Detection.; 2020.

Fujigaki H, Takemura M, Osawa M, Al E. Reliability of serological tests for COVID-19: Comparison of three immunochromatography test kits for SARS-CoV-2 antibodies. medRxiv. 2020. doi:10.1101/2020.06.28.20140475




DOI: http://doi.org/10.11591/ijphs.v10i4.20919

Refbacks

  • There are currently no refbacks.


International Journal of Public Health Science (IJPHS)
p-ISSN: 2252-8806, e-ISSN: 2620-4126

View IJPHS Stats

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.